However, it is not a controlled substance and is not generally considered addictive. Quetiapine, an atypical antipsychotic endowed with weak. This article examines the case of a recent patient on the authors inpatient unit who admitted to a novel route of abuse. Listing a study does not mean it has been evaluated by the u. Fda warns about serious risks and death when combining opioid. Quetiapine for the reduction of cocaine use azc the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Potential benefits of quetiapine in the treatment of. We describe misuse of combinations of gabapentin and quetiapine. History quetiapine, trade name of seroquel, was developed by astra zenca labs, in early 1990s.
Some people, however, abuse it for its ability to produce a state that is close to that of sleeping. Most published case reports of antipsychotic abuse involve quetiapine, although some describe misuse of other agents, including. Patients should be observed closely for signs of seroquel misuse or abuse e. Use in adults 5 the fda also requires that a medication guide be provided with each aripiprazole, olanzapine, quetiapine, and quetiapine xr prescription to alert patients to the risk of suicidal thinking and behavior. Quetiapine oral tablet is a prescription drug used to treat bipolar disorder, schizophrenia, and depression. Intoxication after extreme oral overdose of quetiapine to.
Quetiapine for cocaine use and cravings full text view. Misuse and associated harms of quetiapine and other. The use of quetiapine as a drug to treat various substance use disorders as well as a drug of abuse is examined. Is it an atypical paradigm of drug seeking behavior.
Caution is needed when prescribing quetiapine to patients with a history of alcohol or drug abuse. The misuse potential of quetiapine is likely related to its histaminic blockade coupled with its comparatively mild action at dopamine receptors. Quetiapine is an atypical or secondgeneration antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. Malingered psychotic symptoms and quetiapine abuse in a forensic setting. Quetiapine is unlikely to interfere with the metabolism of. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, prolongation, somnolence, and hyperglycemia. Therefore, clinicians should be cautious when prescribing quetiapine to such patients. In this edition of the interface, we examine the potential risk for misuseabuse that has been inferred with the atypical antipsychotic quetiapine seroquel, wilmington, delaware. Elimination of quetiapine is mainly via hepatic metabolism with a mean terminal halflife of about 6 hours within the proposed clinical dose range. Quetiapine is an antipsychotic medicine that is used to treat schizophrenia in adults and children who are at least years old quetiapine is used to treat bipolar disorder manic depression in adults and children who are at least 10 years old quetiapine is also used together with antidepressant medications to treat major depressive disorder in adults. Quetiapine fumarate seroquel is a pharmaceutical drug in a class of drugs known as atypical antipsychotics. Quetiapine pharmacotherapy for cannabis dependence full. Methods of quetiapine misuse include in gesting pills, inhaling. Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders.
Accordingly, quetiapine substitutes for sedating agents and individuals with a history of alcohol, benzodiazepine, or opiate abuse are particularly at risk. The fda estimates that less than 1% of all serious events are ever reported to it, so the actual number of side effects occurring are most certainly higher. Quetiapine abuse is the use of a drug called quetiapine in a manner for which it isnt prescribed. Is seroquel developing an illicit reputation for misuseabuse. A 42yearold man was admitted to a treatment program after his second arrest for driving under the influence of an. Most reports concern males, and especially those with a history of other psychoactive substance abuse, and personality disorders, often in conflict with the law. While quetiapine s abuse potential in the black market is well known. Quetiapine abuse is relatively common, and is abused far more often. Its available in generic forms and as the brandname drugs seroquel immediaterelease. A combination of fever, severe muscle stiffiness, sweating or a lowered level of. Although the use of quetiapine in patients with a nonpsychotic disorder is increasing, there are few data to suggest that this medication might be beneficial in substance users with no psychotic or bipolar disorder. Read this medication guide before you start taking seroquel and each time you get a refill.
Find out why seroquel is prescribed, side effects of seroquel, seroquel warnings, effects of seroquel during pregnancy, more in plain english. The article discusses potential mechanisms responsible for quetiapine abuse. Intentional recreational abuse of quetiapine compared to. The purpose of this study was to collect pilot data on whether quetiapine may be effective in the reduction of cocaine use and cravings in cocaine dependent individuals. Quetiapine is an atypical antipsychotic approved for the treatment of schizophrenia, bipolar disorder.
Lithium as addon to quetiapine xr in adult patients with. Quetiapine extended release xr and lithium are treatments with proven efficacy in acute mania. Steadystate concentrations are expected to be achieved within two days of dosing. Emergency department visits involving misuse and abuse of. Seroquel, seroquel xr the following information is not intended to endorse any particular medication. To date, two published studies have evaluated the use of quetiapine specifically for the treatment of insomnia. Abuse of combinations of gabapentin and quetiapine. These highlights do not include all the information needed to use seroquel safely and effectively. Here, we present the first case report of an intoxication with an extreme overdose of quetiapine 36 g, ingested by a 32. This randomized study evaluated the efficacy and safety of lithium or placebo as addon to quetiapine xr in adult patients with manic or mixed symptoms of bipolar i disorder. Case reports and poison center data have demonstrated that the secondgeneration antipsychotic quetiapine is being obtained and used for recreational abuse. Quetiapine entered the market in 1997, and in 2008 generated sales of 4. Pdf quetiapine in substance use disorders, abuse and.
Medguide section medication guide seroquel serohkwell quetiapine fumarate tablets. Pdf quetiapine abuse and dependence in psychiatric patients. Seroquel quetiapine fumarate patient information healthyplace. For this study, faers quarterly data files from the first quarter of 2015 2015 q1 through the fourth quarter of 2017 2017 q4 were downloaded. Quetiapine 25 mg filmcoated tablets quetiapine 100 mg filmcoated tablets quetiapine 150 mg filmcoated tablets. The purpose of this study was to describe the relative rates of singlesubstance abuse for different atypical antipsychotics and compare their demographic and clinical features. Quetiapine, an effective atypical antipsychotic that acts by blocking serotonin type 2a, dopamine type 2, histamine type 1, and adrenergic receptors, is a promising treatment for substance use disorders. There have been 37,268 adverse reactions reported to the us fda in connection with seroquel quetiapine. Tell your doctor immediately if you experience any of the following after taking quetiapine tablets. Quetiapine abuse has also been documented, particularly.
According to the helpguide, half of americans living with the severe types of mental illness that seroquel is intended to treat are substance abusers. Quetiapine abuse the first case of abuse of quetiapine was described in 2008 15. Drug list by therapeutic category cardiovascular drugs 01. Quetiapine s effectiveness in treating schizophrenia and bipolar disorder is wellknown. Tation quetiapine 396 y harmv 71 1 2014 insomnia disorder. Sean kim, gayoung lee,eric kim, hyejin jung, and jongwha chang institute of pharmaceutical outcomes and policy, university of kentucky, lexington, kentucky, usa. Intentional recreational abuse of quetiapine compared to other. Highlights of prescribing information these highlights do. Quetiapine in substance use disorders, abuse and dependence possibility. Quetiapine has a chemical structure similar to clozapine and olanzapine, thus was supposed to be a drug with similar efficacy but reduced sideeffects.
Current dsmiv diagnosis of an alcohol or substance use disorder abuse or. A large number of those who abuse this drug are suffering from anxiety or other issues of mood fluctuations, and they selfmedicate with seroquel to ease their discomfort. Quetiapine abuse has again been described 116 a a 29yearold man reported that the local police were disturbing his sleep by electronically monitoring his testicles. Quetiapine fumarate activity is primarily due to the parent drug. Case reports in medical literature suggest that the atypical antipsychotic quetiapine, a medication not previously considered to have abuse potential, is now being subject to misuse and abuse mua. Quetiapine for the reduction of cocaine use full text. Quetiapine pharmacotherapy for cannabis dependence quest. Antagonist drugs block the corresponding receptors in the brain, and replaces them with effects of its own.
397 1162 1146 236 941 776 1030 658 302 409 162 492 675 608 491 524 1269 1463 956 1056 1142 406 1121 980 588 524 593 1363 1019 1374 181 1574 639 35 1218 1356 1371 357 892 532